Lyophilized Nasal Inserts of Atomoxetine HCl Solid Lipid Nanoparticles for Brain Targeting as a Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD): A Pharmacokinetics Study on Rats

The study aims to investigate the ability of lyophilized nasal inserts of nanosized atomoxetine HCl solid lipid nanoparticles (ATM-SLNs) to transport atomoxetine (ATM) directly to the brain and overcome the first-pass metabolism. In this case, 16 formulae of (ATM-SLNs) were prepared using hot melt e...

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Detalles Bibliográficos
Autores principales: Teaima, Mahmoud H., El-Nadi, Merhan Taha, Hamed, Raghda Rabe, El-Nabarawi, Mohamed A., Abdelmonem, Rehab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958713/
https://www.ncbi.nlm.nih.gov/pubmed/37259468
http://dx.doi.org/10.3390/ph16020326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958713/
https://www.ncbi.nlm.nih.gov/pubmed/37259468
http://dx.doi.org/10.3390/ph16020326

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