Cargando…

Discovery of New Heterocyclic/Benzofuran Hybrids as Potential Anti-Inflammatory Agents: Design, Synthesis, and Evaluation of the Inhibitory Activity of Their Related Inflammatory Factors Based on NF-κB and MAPK Signaling Pathways

NF-κB and MAPK are classic inflammation signaling pathways which regulate inflammation signal transmission and induce the expression of many inflammatory factors. Based on the potent anti-inflammatory activity of benzofuran and its derivatives, several new heterocyclic/benzofuran hybrids were first...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yangling, Chen, Rui, Yuan, Renyikun, Huo, Lini, Gao, Hongwei, Zhuo, Youqiong, Chen, Xinxin, Zhang, Chenwei, Yang, Shilin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958778/ https://www.ncbi.nlm.nih.gov/pubmed/36834992 http://dx.doi.org/10.3390/ijms24043575

Ejemplares similares

Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway
por: Wang, Qin-Qin, et al.
Publicado: (2021)

Tanshinone I exerts cardiovascular protective effects in vivo and in vitro through inhibiting necroptosis via Akt/Nrf2 signaling pathway
por: Zhuo, Youqiong, et al.
Publicado: (2021)

Hederasaponin C Alleviates Lipopolysaccharide-Induced Acute Lung Injury In Vivo and In Vitro Through the PIP2/NF-κB/NLRP3 Signaling Pathway
por: Han, Shan, et al.
Publicado: (2022)

Sugarcane leaf polysaccharide exerts a therapeutic effect on cardiovascular diseases through necroptosis
por: Sun, Kaili, et al.
Publicado: (2023)

Oleuropein Attenuates Lipopolysaccharide-Induced Acute Kidney Injury In Vitro and In Vivo by Regulating Toll-Like Receptor 4 Dimerization
por: Cui, Yushun, et al.
Publicado: (2021)

Anemoside B4 protects against Klebsiella pneumoniae- and influenza virus FM1-induced pneumonia via the TLR4/Myd88 signaling pathway in mice
por: He, Jia, et al.
Publicado: (2020)

Fluorinated Benzofuran and Dihydrobenzofuran as Anti-Inflammatory and Potential Anticancer Agents
por: Ayoub, Abeer J., et al.
Publicado: (2023)

Procyanidin A1 Alleviates Inflammatory Response induced by LPS through NF-κB, MAPK, and Nrf2/HO-1 Pathways in RAW264.7 cells
por: Han, Shan, et al.
Publicado: (2019)

Fe-Curcumin Nanozyme-Mediated Reactive Oxygen Species Scavenging and Anti-Inflammation for Acute Lung Injury
por: Yuan, Renyikun, et al.
Publicado: (2021)

Diethyl Blechnic Exhibits Anti-Inflammatory and Antioxidative Activity via the TLR4/MyD88 Signaling Pathway in LPS-Stimulated RAW264.7 Cells
por: He, Jia, et al.
Publicado: (2019)

Discovery of an effective anti-inflammatory agent for inhibiting the activation of NF-κB
por: Yan, Yaoyao, et al.
Publicado: (2023)

An unusual formal migrative cycloaddition of aurone-derived azadienes: synthesis of benzofuran-fused nitrogen heterocycles
por: Feng, Qiang, et al.
Publicado: (2021)

Inhibitory Effects of Palmultang on Inflammatory Mediator Production Related to Suppression of NF-κB and MAPK Pathways and Induction of HO-1 Expression in Macrophages
por: Oh, You-Chang, et al.
Publicado: (2014)

Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase
por: Zhou, Xiang, et al.
Publicado: (2010)

Bis(Benzofuran–1,3-N,N-heterocycle)s as Symmetric and Synthetic Drug Leads against Yellow Fever Virus
por: Gupta, Nitesh K., et al.
Publicado: (2022)

Procyanidin A2, a polyphenolic compound, exerts anti-inflammatory and anti-oxidative activity in lipopolysaccharide-stimulated RAW264.7 cells
por: Wang, Qin-Qin, et al.
Publicado: (2020)

Anti-Inflammatory and Gastroprotective Roles of Rabdosia inflexa through Downregulation of Pro-Inflammatory Cytokines and MAPK/NF-κB Signaling Pathways
por: Akanda, Md Rashedunnabi, et al.
Publicado: (2018)

Tat-ATOX1 inhibits inflammatory responses via regulation of MAPK and NF-κB pathways
por: Kim, Dae Won, et al.
Publicado: (2018)

Xanthatin Alleviates LPS-Induced Inflammatory Response in RAW264.7 Macrophages by Inhibiting NF-κB, MAPK and STATs Activation
por: Liu, Yuanqi, et al.
Publicado: (2022)

Anti-inflammatory activity of flavonols via inhibiting MAPK and NF-κB signaling pathways in RAW264.7 macrophages
por: Zhong, Ruting, et al.
Publicado: (2022)

Rosmarinic Acid Attenuates the Lipopolysaccharide-Provoked Inflammatory Response of Vascular Smooth Muscle Cell via Inhibition of MAPK/NF-κB Cascade
por: Chen, Ching-Pei, et al.
Publicado: (2022)

Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways
por: Zhang, Wenfei, et al.
Publicado: (2021)

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species
por: Xu, Kuo, et al.
Publicado: (2020)

The pyridazine heterocycle in molecular recognition and drug discovery
por: Meanwell, Nicholas A.
Publicado: (2023)

Involvement of MAPK/NF-κB Signaling in the Activation of the Cholinergic Anti-Inflammatory Pathway in Experimental Colitis by Chronic Vagus Nerve Stimulation
por: Sun, Peng, et al.
Publicado: (2013)

Follistatin-like protein 1 promotes inflammatory reactions in nucleus pulposus cells by interacting with the MAPK and NFκB signaling pathways
por: Liu, Yi, et al.
Publicado: (2017)

Anemoside B4 Protects against Acute Lung Injury by Attenuating Inflammation through Blocking NLRP3 Inflammasome Activation and TLR4 Dimerization
por: Yuan, Renyikun, et al.
Publicado: (2020)

Cheongsangbangpung-tang ameliorated the acute inflammatory response via the inhibition of NF-κB activation and MAPK phosphorylation
por: Kim, Seon Young, et al.
Publicado: (2017)

In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways
por: Zhang, Chao, et al.
Publicado: (2019)

Inflammatory Potential of Four Different Phases of Calcium Pyrophosphate Relies on NF-κB Activation and MAPK Pathways
por: Campillo-Gimenez, Laure, et al.
Publicado: (2018)

Inhibiting USP14 ameliorates inflammatory responses in trophoblast cells by suppressing MAPK/NF‐κB signaling
por: Zhao, Yingzi, et al.
Publicado: (2021)

Anti-Inflammatory Effects of Weigela subsessilis Callus Extract via Suppression of MAPK and NF-κB Signaling
por: Lim, Hyeon-Ji, et al.
Publicado: (2021)

Anti‑inflammatory effects of Nypa fruticans Wurmb via NF‑κB and MAPK signaling pathways in macrophages
por: Park, Hye Jeong, et al.
Publicado: (2022)

Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes
por: Dao-Huy, Toan, et al.
Publicado: (2020)

p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease
por: Qi, Xiao-Mei, et al.
Publicado: (2023)

Adrenomedullin protects Leydig cells against lipopolysaccharide-induced oxidative stress and inflammatory reaction via MAPK/NF-κB signalling pathways
por: Hu, Wei, et al.
Publicado: (2017)

Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages
por: Guo, Hongrui, et al.
Publicado: (2019)

Enhanced Anti-Inflammatory Effects of Silibinin and Capsaicin Combination in Lipopolysaccharide-Induced RAW264.7 Cells by Inhibiting NF-κB and MAPK Activation
por: Zheng, Yingying, et al.
Publicado: (2022)

Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
por: Taha, Muhammad, et al.
Publicado: (2020)

Abrine, an IDO1 inhibitor, suppresses the immune escape and enhances the immunotherapy of anti-PD-1 antibody in hepatocellular carcinoma
por: Liang, Xiaowei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ru5ncovvqon02mjjrrvsdo6ubv