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Comparison of Seven Non-Linear Mixed Effect Model-Based Approaches to Test for Treatment Effect

Analyses of longitudinal data with non-linear mixed-effects models (NLMEM) are typically associated with high power, but sometimes at the cost of inflated type I error. Approaches to overcome this problem were published recently, such as model-averaging across drug models (MAD), individual model-ave...

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Detalles Bibliográficos
Autores principales: Chasseloup, Estelle, Karlsson, Mats O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959233/
https://www.ncbi.nlm.nih.gov/pubmed/36839782
http://dx.doi.org/10.3390/pharmaceutics15020460