In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [(11)C]OCM-44 and [(18)F]OCM-50 in Non-Human Primates

Glycogen synthase kinase 3 (GSK-3) is a potential therapeutic target for a range of neurodegenerative and psychiatric disorders. The goal of this work was to evaluate two leading GSK-3 positron emission tomography (PET) radioligands, [(11)C]OCM-44 and [(18)F]OCM-50, in non-human primates to assess t...

Descripción completa

Detalles Bibliográficos
Autores principales: Smart, Kelly, Zheng, Ming-Qiang, Holden, Daniel, Felchner, Zachary, Zhang, Li, Han, Yanjiang, Ropchan, Jim, Carson, Richard E., Vasdev, Neil, Huang, Yiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959234/
https://www.ncbi.nlm.nih.gov/pubmed/37259346
http://dx.doi.org/10.3390/ph16020194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959234/
https://www.ncbi.nlm.nih.gov/pubmed/37259346
http://dx.doi.org/10.3390/ph16020194

Ejemplares similares