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In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [(11)C]OCM-44 and [(18)F]OCM-50 in Non-Human Primates

Glycogen synthase kinase 3 (GSK-3) is a potential therapeutic target for a range of neurodegenerative and psychiatric disorders. The goal of this work was to evaluate two leading GSK-3 positron emission tomography (PET) radioligands, [(11)C]OCM-44 and [(18)F]OCM-50, in non-human primates to assess t...

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Detalles Bibliográficos
Autores principales:	Smart, Kelly, Zheng, Ming-Qiang, Holden, Daniel, Felchner, Zachary, Zhang, Li, Han, Yanjiang, Ropchan, Jim, Carson, Richard E., Vasdev, Neil, Huang, Yiyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959234/ https://www.ncbi.nlm.nih.gov/pubmed/37259346 http://dx.doi.org/10.3390/ph16020194

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