Pyrrolyl and Indolyl α-γ-Diketo Acid Derivatives Acting as Selective Inhibitors of Human Carbonic Anhydrases IX and XII

Solid tumors are active tissues containing hypoxic regions and producing metabolic acids. By decreasing pH, cancer cells create a hostile environment for surrounding host cells and foster tumor growth and progression. By governing acid/base regulation, carbonic anhydrases (CAs) are involved in sever...

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Detalles Bibliográficos
Autores principales: Ialongo, Davide, Messore, Antonella, Madia, Valentina Noemi, Tudino, Valeria, Nocentini, Alessio, Gratteri, Paola, Giovannuzzi, Simone, Supuran, Claudiu T., Nicolai, Alice, Scarpa, Susanna, Taurone, Samanta, Camarda, Michele, Artico, Marco, Papa, Veronica, Saccoliti, Francesco, Scipione, Luigi, Di Santo, Roberto, Costi, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959269/
https://www.ncbi.nlm.nih.gov/pubmed/37259337
http://dx.doi.org/10.3390/ph16020188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959269/
https://www.ncbi.nlm.nih.gov/pubmed/37259337
http://dx.doi.org/10.3390/ph16020188

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