Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma

Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that are directly involved in altered cancer cell metabolism, resulting in cancer aggressiveness and resistance. Dichloroacetic acid (DCA) is the first PDK inhibitor that has entered phase II clinical; however, several side effects...

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Detalles Bibliográficos
Autores principales: Carbone, Daniela, De Franco, Michele, Pecoraro, Camilla, Bassani, Davide, Pavan, Matteo, Cascioferro, Stella, Parrino, Barbara, Cirrincione, Girolamo, Dall’Acqua, Stefano, Moro, Stefano, Gandin, Valentina, Diana, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959349/
https://www.ncbi.nlm.nih.gov/pubmed/36835086
http://dx.doi.org/10.3390/ijms24043679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959349/
https://www.ncbi.nlm.nih.gov/pubmed/36835086
http://dx.doi.org/10.3390/ijms24043679

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