Cargando…
HSPs/STAT3 Interplay Sustains DDR and Promotes Cytokine Release by Primary Effusion Lymphoma Cells
Primary effusion lymphoma (PEL) is a rare and aggressive B-cell lymphoma, against which current therapies usually fail. In the present study, we show that targeting HSPs, such as HSP27, HSP70 and HSP90, could be an efficient strategy to reduce PEL cell survival, as it induces strong DNA damage, whic...
Autores principales: | Gonnella, Roberta, Arena, Andrea, Zarrella, Roberta, Gilardini Montani, Maria Saveria, Santarelli, Roberta, Cirone, Mara |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959463/ https://www.ncbi.nlm.nih.gov/pubmed/36835344 http://dx.doi.org/10.3390/ijms24043933 |
Ejemplares similares
-
IRE1 Alpha/XBP1 Axis Sustains Primary Effusion Lymphoma Cell Survival by Promoting Cytokine Release and STAT3 Activation
por: Gonnella, Roberta, et al.
Publicado: (2021) -
Mechanisms of Sensitivity and Resistance of Primary Effusion Lymphoma to Dimethyl Fumarate (DMF)
por: Gonnella, Roberta, et al.
Publicado: (2022) -
NFE2L2 and STAT3 Converge on Common Targets to Promote Survival of Primary Lymphoma Cells
por: Arena, Andrea, et al.
Publicado: (2023) -
EBV infection of primary colonic epithelial cells causes inflammation, DDR and autophagy dysregulation, effects that may predispose to IBD and carcinogenesis
por: Santarelli, Roberta, et al.
Publicado: (2023) -
3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells
por: Santarelli, Roberta, et al.
Publicado: (2022)