Cargando…
CurQ+, a Next-Generation Formulation of Curcumin, Ameliorates Growth Plate Chondrocyte Stress and Increases Limb Growth in a Mouse Model of Pseudoachondroplasia
Mutations in cartilage oligomeric matrix protein (COMP) causes protein misfolding and accumulation in chondrocytes that compromises skeletal growth and joint health in pseudoachondroplasia (PSACH), a severe dwarfing condition. Using the MT-COMP mice, a murine model of PSACH, we showed that pathologi...
Autores principales: | Hecht, Jacqueline T., Veerisetty, Alka C., Hossain, Mohammad G., Chiu, Frankie, Posey, Karen L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959842/ https://www.ncbi.nlm.nih.gov/pubmed/36835255 http://dx.doi.org/10.3390/ijms24043845 |
Ejemplares similares
-
Joint Degeneration in a Mouse Model of Pseudoachondroplasia: ER Stress, Inflammation, and Block of Autophagy
por: Hecht, Jacqueline T., et al.
Publicado: (2021) -
Early Resveratrol Treatment Mitigates Joint Degeneration and Dampens Pain in a Mouse Model of Pseudoachondroplasia (PSACH)
por: Hecht, Jacqueline T., et al.
Publicado: (2023) -
Pseudoachondroplasia/COMP — translating from the bench to the bedside
por: Posey, Karen LaShea, et al.
Publicado: (2014) -
Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia
por: Piróg, Katarzyna A., et al.
Publicado: (2014) -
Resveratrol Reduces COMPopathy in Mice Through Activation of Autophagy
por: Hecht, Jacqueline T, et al.
Publicado: (2021)