Cargando…

A Highly Conserved Region in BRCA2 Suppresses the RAD51-Interaction Activity of BRC Repeats

SIMPLE SUMMARY: Mammary tumors are the most common tumor type in female dogs and one of the major problems in veterinary oncology. Breast cancer 2, early onset (BRCA2) mutations are associated with tumorigenesis in humans and dogs. BRCA2 is a DNA damage repair protein that interacts with RAD51, anot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Zida, Kitano, Taisuke, Morimatsu, Masami, Ochiai, Kazuhiko, Ishiguro-Oonuma, Toshina, Oosumi, Kosuke, Lin, Xianghui, Orino, Koichi, Yoshikawa, Yasunaga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959916/ https://www.ncbi.nlm.nih.gov/pubmed/36851449 http://dx.doi.org/10.3390/vetsci10020145

Ejemplares similares

Identification of the core motif of the BRCA2 C-terminal RAD51-binding domain by comparing canine and human BRCA2
por: YOSHIKAWA, Yasunaga, et al.
Publicado: (2021)

BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents
por: Zhu, Zida, et al.
Publicado: (2022)

Reduced canine BRCA2 expression levels in mammary gland tumors
por: Yoshikawa, Yasunaga, et al.
Publicado: (2015)

Effects of the Missense Mutations in Canine BRCA2 on BRC Repeat 3 Functions and Comparative Analyses between Canine and Human BRC Repeat 3
por: Yoshikawa, Yasunaga, et al.
Publicado: (2012)

BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair
por: Jimenez-Sainz, Judit, et al.
Publicado: (2022)

Establishment of a PCR analysis method for canine BRCA2
por: Yoshikawa, Yasunaga, et al.
Publicado: (2012)

Reduced translation efficiency due to novel splicing variants in 5′ untranslated region and identification of novel cis-regulatory elements in canine and human BRCA2
por: Yoshikawa, Yasunaga, et al.
Publicado: (2021)

Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase
por: Rajendra, Eeson, et al.
Publicado: (2010)

Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity
por: Chatterjee, Gouri, et al.
Publicado: (2016)

Plasmodium berghei Brca2 is required for normal development and differentiation in mice and mosquitoes
por: Yoshikawa, Yasunaga, et al.
Publicado: (2022)

Divergent binding mode for a protozoan BRC repeat to RAD51
por: Pantelejevs, Teodors, et al.
Publicado: (2022)

A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange
por: Shivji, Mahmud K. K., et al.
Publicado: (2006)

Canine Mammary Tumor Cell Lines Derived from Metastatic Foci Show Increased RAD51 Expression but Diminished Radioresistance via p21 Inhibition
por: Shimakawa, Kei, et al.
Publicado: (2022)

Interrogation of the Protein-Protein Interactions between Human BRCA2 BRC Repeats and RAD51 Reveals Atomistic Determinants of Affinity
por: Cole, Daniel J., et al.
Publicado: (2011)

Design of Potent Inhibitors of Human RAD51 Recombinase Based on BRC Motifs of BRCA2 Protein: Modeling and Experimental Validation of a Chimera Peptide
por: Nomme, Julian, et al.
Publicado: (2010)

Tumor suppressor REIC/DKK-3 and co-chaperone SGTA: Their interaction and roles in the androgen sensitivity
por: Ochiai, Kazuhiko, et al.
Publicado: (2015)

Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics
por: Trenaman, Anna, et al.
Publicado: (2013)

Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction
por: Subramanyam, Shyamal, et al.
Publicado: (2013)

Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations
por: Gonzalez, R, et al.
Publicado: (1999)

Non-Recombinogenic Functions of Rad51, BRCA2, and Rad52 in DNA Damage Tolerance
por: Prado, Félix
Publicado: (2021)

Purified human BRCA2 stimulates RAD51-mediated recombination
por: Jensen, Ryan B., et al.
Publicado: (2010)

Genetic instability in the RAD51 and BRCA1 regions in breast cancer
por: Nowacka-Zawisza, Maria, et al.
Publicado: (2006)

Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2
por: Appleby, Robert, et al.
Publicado: (2023)

BRC criteria revised.
Publicado: (1996)

Clinical Characteristics of Ovarian Cancer Classified by BRCA1, BRCA2, and RAD51C Status
por: Cunningham, J. M., et al.
Publicado: (2014)

BRCA2 Acts as RAD51 Loader to Facilitate Telomere Replication and Capping
por: Badie, Sophie, et al.
Publicado: (2010)

Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction
por: Sidhu, Arshdeep, et al.
Publicado: (2020)

Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes
por: Deveryshetty, Jaigeeth, et al.
Publicado: (2023)

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
por: Scott, Duncan E., et al.
Publicado: (2021)

Roles of XRCC2, RAD51B and RAD51D in RAD51-Independent SSA Recombination
por: Serra, Heïdi, et al.
Publicado: (2013)

Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor
por: Greenhough, Luke A., et al.
Publicado: (2023)

The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination
por: Qing, Yong, et al.
Publicado: (2011)

The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic Entry
por: Ayoub, Nabieh, et al.
Publicado: (2009)

Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum
por: Genois, Marie-Michelle, et al.
Publicado: (2012)

Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair
por: Sánchez, Humberto, et al.
Publicado: (2017)

BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA
por: Bell, Jason C., et al.
Publicado: (2023)

Binding Analysis of Human Immunoglobulin G as a Zinc-Binding Protein
por: Yamanaka, Yu, et al.
Publicado: (2016)

Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51
por: Heijink, Anne Margriet, et al.
Publicado: (2022)

Homologous Pairing Activities of Two Rice RAD51 Proteins, RAD51A1 and RAD51A2
por: Morozumi, Yuichi, et al.
Publicado: (2013)

Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats
por: ISHIGURO-OONUMA, Toshina, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_krom71hp74v3ugjifkrm5tfv8l