Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production

Amyloid-β peptides (Aβs) are produced via cleavage of the transmembrane region of the amyloid precursor protein (APP) by γ-secretase and are responsible for Alzheimer’s disease. Familial Alzheimer’s disease (FAD) is associated with APP mutations that disrupt the cleavage reaction and increase the pr...

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Detalles Bibliográficos
Autores principales: Suzuki, Ryota, Takahashi, Haruka, Yoshida, Chika, Hidaka, Masafumi, Ogawa, Tomohisa, Futai, Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959964/
https://www.ncbi.nlm.nih.gov/pubmed/36835396
http://dx.doi.org/10.3390/ijms24043970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959964/
https://www.ncbi.nlm.nih.gov/pubmed/36835396
http://dx.doi.org/10.3390/ijms24043970

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