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Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production

Amyloid-β peptides (Aβs) are produced via cleavage of the transmembrane region of the amyloid precursor protein (APP) by γ-secretase and are responsible for Alzheimer’s disease. Familial Alzheimer’s disease (FAD) is associated with APP mutations that disrupt the cleavage reaction and increase the pr...

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Detalles Bibliográficos
Autores principales:	Suzuki, Ryota, Takahashi, Haruka, Yoshida, Chika, Hidaka, Masafumi, Ogawa, Tomohisa, Futai, Eugene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959964/ https://www.ncbi.nlm.nih.gov/pubmed/36835396 http://dx.doi.org/10.3390/ijms24043970

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