Insertion of an Amphipathic Linker in a Tetrapodal Tryptophan Derivative Leads to a Novel and Highly Potent Entry Inhibitor of Enterovirus A71 Clinical Isolates

AL-471, the leading exponent of a class of potent HIV and enterovirus A71 (EV-A71) entry inhibitors discovered in our research group, contains four l-tryptophan (Trp) units bearing an aromatic isophthalic acid directly attached to the C2 position of each indole ring. Starting from AL-471, we (i) rep...

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Detalles Bibliográficos
Autores principales: Martí-Marí, Olaia, Abdelnabi, Rana, Schols, Dominique, Neyts, Johan, Camarasa, María-José, Gago, Federico, San-Félix, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959982/
https://www.ncbi.nlm.nih.gov/pubmed/36834952
http://dx.doi.org/10.3390/ijms24043539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959982/
https://www.ncbi.nlm.nih.gov/pubmed/36834952
http://dx.doi.org/10.3390/ijms24043539

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