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Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer

In recent years, 4-phenylbutyric acid (4-PBA), an FDA-approved drug, has increasingly been used as a nonspecific chemical chaperone in vitro and in vitro, but its pharmacodynamics is still not clear. In this context, we developed and validated a Liquid Chromatography–High Resolution Mass Spectrometr...

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Detalles Bibliográficos
Autores principales: Villani, Salvatore, Dematteis, Giulia, Tapella, Laura, Gagliardi, Mara, Lim, Dmitry, Corazzari, Marco, Aprile, Silvio, Del Grosso, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960049/
https://www.ncbi.nlm.nih.gov/pubmed/37259441
http://dx.doi.org/10.3390/ph16020298