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An in vivo phosphoregulation paradox for focal adhesions

Focal adhesions (FAs) dynamics regulate single cell migration. In this issue, Xue et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202206078) show that Y118 phosphorylation on Paxilin, a key FA protein, limits migration of cells in vivo. Unphosphorylated Paxilin is necessary for FA disassembl...

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Detalles Bibliográficos
Autor principal: Tanner, Kandice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960130/
https://www.ncbi.nlm.nih.gov/pubmed/36795454
http://dx.doi.org/10.1083/jcb.202301060