An in vivo phosphoregulation paradox for focal adhesions

Focal adhesions (FAs) dynamics regulate single cell migration. In this issue, Xue et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202206078) show that Y118 phosphorylation on Paxilin, a key FA protein, limits migration of cells in vivo. Unphosphorylated Paxilin is necessary for FA disassembl...

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Detalles Bibliográficos
Autor principal: Tanner, Kandice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960130/
https://www.ncbi.nlm.nih.gov/pubmed/36795454
http://dx.doi.org/10.1083/jcb.202301060
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author Tanner, Kandice
author_facet Tanner, Kandice
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description Focal adhesions (FAs) dynamics regulate single cell migration. In this issue, Xue et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202206078) show that Y118 phosphorylation on Paxilin, a key FA protein, limits migration of cells in vivo. Unphosphorylated Paxilin is necessary for FA disassembly and cell motility. Their findings directly contradict results from in vitro experiments, emphasizing the need for recreating the in vivo complexity to understand how cells behave in their native environments.
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spelling pubmed-99601302023-08-16 An in vivo phosphoregulation paradox for focal adhesions Tanner, Kandice J Cell Biol Spotlight Focal adhesions (FAs) dynamics regulate single cell migration. In this issue, Xue et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202206078) show that Y118 phosphorylation on Paxilin, a key FA protein, limits migration of cells in vivo. Unphosphorylated Paxilin is necessary for FA disassembly and cell motility. Their findings directly contradict results from in vitro experiments, emphasizing the need for recreating the in vivo complexity to understand how cells behave in their native environments. Rockefeller University Press 2023-02-16 /pmc/articles/PMC9960130/ /pubmed/36795454 http://dx.doi.org/10.1083/jcb.202301060 Text en This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply. https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Tanner, Kandice
An in vivo phosphoregulation paradox for focal adhesions
title An in vivo phosphoregulation paradox for focal adhesions
title_full An in vivo phosphoregulation paradox for focal adhesions
title_fullStr An in vivo phosphoregulation paradox for focal adhesions
title_full_unstemmed An in vivo phosphoregulation paradox for focal adhesions
title_short An in vivo phosphoregulation paradox for focal adhesions
title_sort in vivo phosphoregulation paradox for focal adhesions
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960130/
https://www.ncbi.nlm.nih.gov/pubmed/36795454
http://dx.doi.org/10.1083/jcb.202301060
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