Efficient prioritization of CRISPR screen hits by accounting for targeting efficiency of guide RNA

BACKGROUND: CRISPR-based screens are revolutionizing drug discovery as tools to identify genes whose ablation induces a phenotype of interest. For instance, CRISPR-Cas9 screening has been successfully used to identify novel therapeutic targets in cancer where disruption of genes leads to decreased v...

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Detalles Bibliográficos
Autores principales: Park, Byung-Sun, Jeon, Heeju, Chi, Sung-Gil, Kim, Tackhoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960226/
https://www.ncbi.nlm.nih.gov/pubmed/36829149
http://dx.doi.org/10.1186/s12915-023-01536-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960226/
https://www.ncbi.nlm.nih.gov/pubmed/36829149
http://dx.doi.org/10.1186/s12915-023-01536-y

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