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Efficient prioritization of CRISPR screen hits by accounting for targeting efficiency of guide RNA
BACKGROUND: CRISPR-based screens are revolutionizing drug discovery as tools to identify genes whose ablation induces a phenotype of interest. For instance, CRISPR-Cas9 screening has been successfully used to identify novel therapeutic targets in cancer where disruption of genes leads to decreased v...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960226/ https://www.ncbi.nlm.nih.gov/pubmed/36829149 http://dx.doi.org/10.1186/s12915-023-01536-y |