Lethal Caspase-1/4-Dependent Injury Occurs in the First Minutes of Coronary Reperfusion and Requires Calpain Activity

To study the relationship between caspase-1/4 and reperfusion injury, we measured infarct size (IS) in isolated mouse hearts undergoing 50 min global ischemia/2 h reperfusion. Starting VRT-043198 (VRT) at reperfusion halved IS. The pan-caspase inhibitor emricasan duplicated VRT’s protection. IS in c...

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Detalles Bibliográficos
Autores principales: Yang, Xi-Ming, Cohen, Michael V., Sayner, Sarah, Audia, Jonathon P., Downey, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960231/
https://www.ncbi.nlm.nih.gov/pubmed/36835212
http://dx.doi.org/10.3390/ijms24043801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960231/
https://www.ncbi.nlm.nih.gov/pubmed/36835212
http://dx.doi.org/10.3390/ijms24043801

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