Design, Synthesis, Biological Evaluation, and Molecular Dynamics Simulation of Influenza Polymerase PB2 Inhibitors

The PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRp) has been identified as a promising target for the treatment of influenza. To expand the chemical space of the known influenza polymerase PB2 inhibitor–pimodivir (formerly VX-787) and improve its pharmacokinetic profile, two pimodiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xinhong, Xu, Yijie, Li, Wei, Che, Jinjing, Zhao, Xu, Cao, Ruyuan, Li, Xingzhou, Li, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960307/
https://www.ncbi.nlm.nih.gov/pubmed/36838837
http://dx.doi.org/10.3390/molecules28041849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960307/
https://www.ncbi.nlm.nih.gov/pubmed/36838837
http://dx.doi.org/10.3390/molecules28041849

Ejemplares similares