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Design, Synthesis, Biological Evaluation, and Molecular Dynamics Simulation of Influenza Polymerase PB2 Inhibitors

The PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRp) has been identified as a promising target for the treatment of influenza. To expand the chemical space of the known influenza polymerase PB2 inhibitor–pimodivir (formerly VX-787) and improve its pharmacokinetic profile, two pimodiv...

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Detalles Bibliográficos
Autores principales:	Li, Xinhong, Xu, Yijie, Li, Wei, Che, Jinjing, Zhao, Xu, Cao, Ruyuan, Li, Xingzhou, Li, Song
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960307/ https://www.ncbi.nlm.nih.gov/pubmed/36838837 http://dx.doi.org/10.3390/molecules28041849

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