Cargando…

Freeze-Drying of Pharmaceuticals in Vials Nested in a Rack System—Part I: Freezing Behaviour

The distribution of biopharmaceuticals often requires either ultra-cold conditions or lyophilisation. In both cases, the drug product is frozen and, thus, exposed to similar stress conditions, which can be detrimental to its quality. However, these stresses can be inhibited or mitigated by a suitabl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pisano, Roberto, Artusio, Fiora, Adami, Marco, Barresi, Antonello A., Fissore, Davide, Frare, Maria Chiara, Zanetti, Francesco, Zunino, Gabriele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960346/ https://www.ncbi.nlm.nih.gov/pubmed/36839958 http://dx.doi.org/10.3390/pharmaceutics15020635

Ejemplares similares

The Freeze-Drying of Pharmaceuticals in Vials Nested in a Rack System—Part II: Primary Drying Behaviour
por: Artusio, Fiora, et al.
Publicado: (2023)

New Trends in Freeze-Drying of Pharmaceutical Products
por: Pisano, Roberto, et al.
Publicado: (2023)

On the Use of Temperature Measurements as a Process Analytical Technology (PAT) for the Monitoring of a Pharmaceutical Freeze-Drying Process
por: Vallan, Alberto, et al.
Publicado: (2023)

Investigation of the Freezing Phenomenon in Vials Using an Infrared Camera
por: Harguindeguy, Maitê, et al.
Publicado: (2021)

Editorial: Freeze-Drying and Process Analytical Technology for Pharmaceuticals
por: Fissore, Davide, et al.
Publicado: (2018)

Model-Based PAT for Quality Management in Pharmaceuticals Freeze-Drying: State of the Art
por: Fissore, Davide
Publicado: (2017)

A comparative study of freeze-drying heat transfer in polymeric vials and glass vials
por: Sarmadi, Morteza, et al.
Publicado: (2023)

Evaluation of Packaging Materials in Freeze-Drying: Use of Polymer Caps and Nested Vials and Their Impact on Process and Product Attributes
por: Wenzel, Tim, et al.
Publicado: (2021)

Molded Vial Manufacturing and Its Impact on Heat Transfer during Freeze-Drying: Vial Geometry Considerations
por: Wenzel, Tim, et al.
Publicado: (2021)

Supporting data and methods for the multi-scale modelling of freeze-drying of microparticles in packed-beds
por: Capozzi, Luigi C., et al.
Publicado: (2018)

Micro Freeze-Dryer and Infrared-Based PAT: Novel Tools for Primary Drying Design Space Determination of Freeze-Drying Processes
por: Harguindeguy, Maitê, et al.
Publicado: (2021)

Energy Transfer in Vials Nested in a Rack System During Lyophilization
por: Daller, Sarah, et al.
Publicado: (2020)

The Effect of Human Error on the Temperature Monitoring and Control of Freeze Drying Processes by Means of Thermocouples
por: Demichela, Micaela, et al.
Publicado: (2018)

Surface Treatment of Glass Vials for Lyophilization: Implications for Vacuum-Induced Surface Freezing
por: Regis, Francesco, et al.
Publicado: (2021)

Temperature and Heat Transfer Control During Freeze Drying. Effect of Vial Holders and Influence of Pressure
por: Palmkron, Shuai Bai, et al.
Publicado: (2022)

Infrared Thermography for Monitoring of Freeze Drying Processes—Part 2: Monitoring of Temperature on the Surface and Vertically in Cuvettes during Freeze Drying of a Pharmaceutical Formulation
por: Emteborg, Håkan, et al.
Publicado: (2022)

Minimizing Oxidation of Freeze-Dried Monoclonal Antibodies in Polymeric Vials Using a Smart Packaging Approach
por: Härdter, Nicole, et al.
Publicado: (2021)

Low-cost modular chromatography column rack and vial holders
por: Schaufler, Ruby L., et al.
Publicado: (2022)

The Effect of Freezing and Freeze-drying on the Transplantation of Sarcoma 37
por: Warner, P. T. J. C. P., et al.
Publicado: (1950)

Comparative Studies of Different Preservation Methods and Relative Freeze-Drying Formulations for Extracellular Vesicle Pharmaceutical Applications
por: Susa, Francesca, et al.
Publicado: (2023)

Computational Fluid Dynamics data for improving freeze-dryers design
por: Barresi, Antonello A., et al.
Publicado: (2018)

Observations on the Changing Shape of the Ice Mass and the Determination of the Sublimation End Point in Freeze-Drying: An Application for Through-Vial Impedance Spectroscopy (TVIS)
por: Pandya, Bhaskar, et al.
Publicado: (2021)

Cryopreservation and freeze-drying protocols /
Publicado: (2015)

Cryopreservation and freeze-drying protocols /
Publicado: (1995)

Freeze-Drying Technology in Foods
por: Prosapio, Valentina, et al.
Publicado: (2020)

Self-Assembled Monolayers As a Tool to Investigate the Effect of Surface Chemistry on Protein Nucleation
por: Artusio, Fiora, et al.
Publicado: (2023)

To freeze or not to freeze
por: Bangasser, Debra
Publicado: (2015)

Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying
por: Nuytten, Gust, et al.
Publicado: (2021)

Stains from Freeze-Dried Drops
por: Jambon-Puillet, Etienne
Publicado: (2019)

Freeze-Drying of Plant-Based Foods
por: Bhatta, Sagar, et al.
Publicado: (2020)

Freeze-drying for the preservation of immunoengineering products
por: Kommineni, Nagavendra, et al.
Publicado: (2022)

The Impact of Freeze-Drying Conditions on the Physico-Chemical Properties and Bioactive Compounds of a Freeze-Dried Orange Puree
por: Silva-Espinoza, Marilú A., et al.
Publicado: (2019)

Preparation of Chitosan Nanocompositeswith a Macroporous Structure by Unidirectional Freezing and Subsequent Freeze-Drying
por: Aranaz, Inmaculada, et al.
Publicado: (2014)

The Effect of Pre-Treatment (Blanching, Ultrasound and Freezing) on Quality of Freeze-Dried Red Beets
por: Ciurzyńska, Agnieszka, et al.
Publicado: (2021)

Effect of Encapsulation Techniques on Aroma Retention of Pistacia terebinthus L. Fruit Oil: Spray Drying, Spray Freeze Drying, and Freeze Drying
por: Yaman, Delal Meryem, et al.
Publicado: (2023)

Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process
por: Ccorahua, Robert, et al.
Publicado: (2018)

PRESERVATION OF STOCK CULTURES OF BACTERIA BY FREEZING AND DRYING
por: Swift, Homer F.
Publicado: (1921)

Preparation of Co-Amorphous Systems by Freeze-Drying
por: Wostry, Melvin, et al.
Publicado: (2020)

Stabilisation of COVID-19 diagnostics by freeze-drying
por: Ward, Kevin
Publicado: (2020)

Characterization of the Aroma of an Instant White Tea Dried by Freeze Drying
por: Ni, Hui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1bmlbi6ifchbj27gl0lbtf4jeu