Cancer Metabolism: Fasting Reset, the Keto-Paradox and Drugs for Undoing

In tumor cells, ketolysis “via” succinyl-CoA: 3-oxoacid-CoAtransferase (SCOT) and acetyl-CoA acetyltransferase 1 (ACAT1) is a major source of mitochondrial acetyl-CoA. Active ACAT1 tetramers stabilize by tyrosine phosphorylation, which facilitates the SCOT reaction and ketolysis. Tyrosine phosphoryl...

Descripción completa

Detalles Bibliográficos
Autores principales: Israël, Maurice, Berg, Eric, Tenenbaum, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960359/
https://www.ncbi.nlm.nih.gov/pubmed/36836124
http://dx.doi.org/10.3390/jcm12041589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960359/
https://www.ncbi.nlm.nih.gov/pubmed/36836124
http://dx.doi.org/10.3390/jcm12041589

Ejemplares similares