“Dual Anta-Inhibitors” of the A(2A) Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies

Based on a screening of a chemical library of A(2A) adenosine receptor (AR) antagonists, a series of di- and tri-substituted adenine derivatives were synthesized and tested for their ability to inhibit the activity of the enzyme casein kinase 1 delta (CK1δ) and to bind adenosine receptors (ARs). Som...

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Detalles Bibliográficos
Autores principales: Spinaci, Andrea, Buccioni, Michela, Catarzi, Daniela, Cui, Chang, Colotta, Vittoria, Dal Ben, Diego, Cescon, Eleonora, Francucci, Beatrice, Grieco, Ilenia, Lambertucci, Catia, Marucci, Gabriella, Bassani, Davide, Pavan, Matteo, Varano, Flavia, Federico, Stephanie, Spalluto, Giampiero, Moro, Stefano, Volpini, Rosaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960553/
https://www.ncbi.nlm.nih.gov/pubmed/37259317
http://dx.doi.org/10.3390/ph16020167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960553/
https://www.ncbi.nlm.nih.gov/pubmed/37259317
http://dx.doi.org/10.3390/ph16020167

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