Cargando…
Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson’s Model
Previous work revealed an inverse correlation between tobacco smoking and Parkinson’s disease (PD) that is associated with nicotine-induced neuroprotection of dopaminergic (DA) neurons against nigrostriatal damage in PD primates and rodent models. Nicotine, a neuroactive component of tobacco, can di...
Autores principales: | Lai, Jessica IChi, Porcu, Alessandra, Romoli, Benedetto, Keisler, Maria, Manfredsson, Fredric P., Powell, Susan B., Dulcis, Davide |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960650/ https://www.ncbi.nlm.nih.gov/pubmed/36835612 http://dx.doi.org/10.3390/ijms24044204 |
Ejemplares similares
-
Loss of Functional Alpha-Synuclein: A Toxic Event in Parkinson’s Disease?
por: Kanaan, Nicholas M., et al.
Publicado: (2012) -
Gene Therapy to Modulate Alpha-Synuclein in Synucleinopathies
por: Sandoval, Ivette M., et al.
Publicado: (2021) -
The contribution of alpha synuclein to neuronal survival and function – Implications for Parkinson's disease
por: Benskey, Matthew J., et al.
Publicado: (2016) -
Sequential or Simultaneous Injection of Preformed Fibrils and AAV Overexpression of Alpha-Synuclein Are Equipotent in Producing Relevant Pathology and Behavioral Deficits
por: Negrini, Matilde, et al.
Publicado: (2022) -
Characterisation of functional deficits induced by AAV overexpression of alpha-synuclein in rats
por: Gubinelli, F., et al.
Publicado: (2022)