Novel Silicone-Grafted Alginate as a Drug Delivery Scaffold: Pharmaceutical Characterization of Gliclazide-Loaded Silicone-Based Composite Microcapsules

A novel gliclazide-loaded elastomeric carbohydrate pharmaceutical vehicle was successfully developed. This new siliconized alginate platform showed pseudoplastic rheology with a zeta potential ranging from (−43.8 mV to −75.5 mV). A Buchi-B390 encapsulator was employed to formulate different types of...

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Autores principales: Gedawy, Ahmed, Luna, Giuseppe, Martinez, Jorge, Brown, Daniel, Al-Salami, Hani, Dass, Crispin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960830/
https://www.ncbi.nlm.nih.gov/pubmed/36839852
http://dx.doi.org/10.3390/pharmaceutics15020530
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author Gedawy, Ahmed
Luna, Giuseppe
Martinez, Jorge
Brown, Daniel
Al-Salami, Hani
Dass, Crispin R.
author_facet Gedawy, Ahmed
Luna, Giuseppe
Martinez, Jorge
Brown, Daniel
Al-Salami, Hani
Dass, Crispin R.
author_sort Gedawy, Ahmed
collection PubMed
description A novel gliclazide-loaded elastomeric carbohydrate pharmaceutical vehicle was successfully developed. This new siliconized alginate platform showed pseudoplastic rheology with a zeta potential ranging from (−43.8 mV to −75.5 mV). A Buchi-B390 encapsulator was employed to formulate different types of silicone-grafted alginate microcapsules loaded with gliclazide relying on the vibrational ionic gelation technology. The use of tetraethyl orthosilicate (TEOS) to crosslink the silicone elastomer (hydroxy terminated polydimethylsiloxane) of this new platform had improved the gliclazide encapsulation (>92.13% ± 0.76) of the free-flowing composite microcapsules, which showed good mechanical durability (up to 12 h in PBS pH 6.8) and promising results to sustain the drug release.
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spelling pubmed-99608302023-02-26 Novel Silicone-Grafted Alginate as a Drug Delivery Scaffold: Pharmaceutical Characterization of Gliclazide-Loaded Silicone-Based Composite Microcapsules Gedawy, Ahmed Luna, Giuseppe Martinez, Jorge Brown, Daniel Al-Salami, Hani Dass, Crispin R. Pharmaceutics Article A novel gliclazide-loaded elastomeric carbohydrate pharmaceutical vehicle was successfully developed. This new siliconized alginate platform showed pseudoplastic rheology with a zeta potential ranging from (−43.8 mV to −75.5 mV). A Buchi-B390 encapsulator was employed to formulate different types of silicone-grafted alginate microcapsules loaded with gliclazide relying on the vibrational ionic gelation technology. The use of tetraethyl orthosilicate (TEOS) to crosslink the silicone elastomer (hydroxy terminated polydimethylsiloxane) of this new platform had improved the gliclazide encapsulation (>92.13% ± 0.76) of the free-flowing composite microcapsules, which showed good mechanical durability (up to 12 h in PBS pH 6.8) and promising results to sustain the drug release. MDPI 2023-02-04 /pmc/articles/PMC9960830/ /pubmed/36839852 http://dx.doi.org/10.3390/pharmaceutics15020530 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gedawy, Ahmed
Luna, Giuseppe
Martinez, Jorge
Brown, Daniel
Al-Salami, Hani
Dass, Crispin R.
Novel Silicone-Grafted Alginate as a Drug Delivery Scaffold: Pharmaceutical Characterization of Gliclazide-Loaded Silicone-Based Composite Microcapsules
title Novel Silicone-Grafted Alginate as a Drug Delivery Scaffold: Pharmaceutical Characterization of Gliclazide-Loaded Silicone-Based Composite Microcapsules
title_full Novel Silicone-Grafted Alginate as a Drug Delivery Scaffold: Pharmaceutical Characterization of Gliclazide-Loaded Silicone-Based Composite Microcapsules
title_fullStr Novel Silicone-Grafted Alginate as a Drug Delivery Scaffold: Pharmaceutical Characterization of Gliclazide-Loaded Silicone-Based Composite Microcapsules
title_full_unstemmed Novel Silicone-Grafted Alginate as a Drug Delivery Scaffold: Pharmaceutical Characterization of Gliclazide-Loaded Silicone-Based Composite Microcapsules
title_short Novel Silicone-Grafted Alginate as a Drug Delivery Scaffold: Pharmaceutical Characterization of Gliclazide-Loaded Silicone-Based Composite Microcapsules
title_sort novel silicone-grafted alginate as a drug delivery scaffold: pharmaceutical characterization of gliclazide-loaded silicone-based composite microcapsules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960830/
https://www.ncbi.nlm.nih.gov/pubmed/36839852
http://dx.doi.org/10.3390/pharmaceutics15020530
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