Gain-of-Function p53N236S Mutation Drives the Bypassing of HRas(V12)-Induced Cellular Senescence via PGC–1α

One of the key steps in tumorigenic transformation is immortalization in which cells bypass cancer-initiating barriers such as senescence. Senescence can be triggered by either telomere erosion or oncogenic stress (oncogene-induced senescence, OIS) and undergo p53- or Rb-dependent cell cycle arrest....

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Detalles Bibliográficos
Autores principales: Yang, Hao, Zhang, Ke, Guo, Yusheng, Guo, Xin, Hou, Kailong, Hou, Jing, Luo, Ying, Liu, Jing, Jia, Shuting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960896/
https://www.ncbi.nlm.nih.gov/pubmed/36835200
http://dx.doi.org/10.3390/ijms24043790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960896/
https://www.ncbi.nlm.nih.gov/pubmed/36835200
http://dx.doi.org/10.3390/ijms24043790

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