Convenient Solid-Phase Attachment of Small-Molecule Ligands to Oligonucleotides via a Biodegradable Acid-Labile P-N-Bond

One of the key problems in the design of therapeutic and diagnostic oligonucleotides is the attachment of small-molecule ligands for targeted deliveries in such a manner that provides the controlled release of the oligonucleotide at a certain moment. Here, we propose a novel, convenient approach for...

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Detalles Bibliográficos
Autores principales: Kropacheva, Nadezhda O., Golyshkin, Arseniy A., Vorobyeva, Mariya A., Meschaninova, Mariya I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961013/
https://www.ncbi.nlm.nih.gov/pubmed/36838892
http://dx.doi.org/10.3390/molecules28041904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961013/
https://www.ncbi.nlm.nih.gov/pubmed/36838892
http://dx.doi.org/10.3390/molecules28041904

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