4-1BB-Based CAR T Cells Effectively Reverse Exhaustion and Enhance the Anti-Tumor Immune Response through Autocrine PD-L1 scFv Antibody

Exhaustion of chimeric antigen receptor (CAR) T cells is one of the limitations for CAR T efficacy in solid tumors and for tumor recurrence after initial CAR T treatment. Tumor treatment with a combination of programmed cell death receptor-1 (PD-1)/programmed cell death ligand-1 (PD-L1) blockage and...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Kang, Feng, Xiangming, Chai, Zhirong, Wang, Zhenzhen, Liu, Zheng, Yan, Zhanchao, Wang, Yanming, Zhang, Shoutao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961031/
https://www.ncbi.nlm.nih.gov/pubmed/36835603
http://dx.doi.org/10.3390/ijms24044197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961031/
https://www.ncbi.nlm.nih.gov/pubmed/36835603
http://dx.doi.org/10.3390/ijms24044197

Ejemplares similares