Inactivation of the UL37 Deamidase Enhances Virus Replication and Spread of the HSV-1(VC2) Oncolytic Vaccine Strain and Secretion of GM-CSF

The HSV-1 (VC2) live-attenuated vaccine strain was engineered with specific deletions in the amino termini of glycoprotein K (gK) and membrane protein UL20, rendering the virus unable to enter neurons and establish latency. VC2 replicates efficiently in epithelial cell culture but produces lower vir...

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Detalles Bibliográficos
Autores principales: Clark, Carolyn M., Jambunathan, Nithya, Collantes, Therese M. A., Kousoulas, Konstantin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961126/
https://www.ncbi.nlm.nih.gov/pubmed/36851581
http://dx.doi.org/10.3390/v15020367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961126/
https://www.ncbi.nlm.nih.gov/pubmed/36851581
http://dx.doi.org/10.3390/v15020367

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