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Inactivation of the UL37 Deamidase Enhances Virus Replication and Spread of the HSV-1(VC2) Oncolytic Vaccine Strain and Secretion of GM-CSF

The HSV-1 (VC2) live-attenuated vaccine strain was engineered with specific deletions in the amino termini of glycoprotein K (gK) and membrane protein UL20, rendering the virus unable to enter neurons and establish latency. VC2 replicates efficiently in epithelial cell culture but produces lower vir...

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Detalles Bibliográficos
Autores principales:	Clark, Carolyn M., Jambunathan, Nithya, Collantes, Therese M. A., Kousoulas, Konstantin G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961126/ https://www.ncbi.nlm.nih.gov/pubmed/36851581 http://dx.doi.org/10.3390/v15020367

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