Inhibition of Xanthine Oxidase Protects against Diabetic Kidney Disease through the Amelioration of Oxidative Stress via VEGF/VEGFR Axis and NOX-FoxO3a-eNOS Signaling Pathway

Xanthine oxidase (XO) is an important source of reactive oxygen species. This study investigated whether XO inhibition exerts renoprotective effects by inhibiting vascular endothelial growth factor (VEGF) and NADPH oxidase (NOX) in diabetic kidney disease (DKD). Febuxostat (5 mg/kg) was administered...

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Detalles Bibliográficos
Autores principales: Yang, Keum-Jin, Choi, Won Jung, Chang, Yoon-Kyung, Park, Cheol Whee, Kim, Suk Young, Hong, Yu Ah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961241/
https://www.ncbi.nlm.nih.gov/pubmed/36835220
http://dx.doi.org/10.3390/ijms24043807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961241/
https://www.ncbi.nlm.nih.gov/pubmed/36835220
http://dx.doi.org/10.3390/ijms24043807

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