Pharmacokinetics of Tamoxifen and Its Major Metabolites and the Effect of the African Ancestry Specific CYP2D6*17 Variant on the Formation of the Active Metabolite, Endoxifen

Tamoxifen (TAM) is widely used in the treatment of hormone receptor-positive breast cancer. TAM is metabolized into the active secondary metabolite endoxifen (ENDO), primarily by CYP2D6. We aimed to investigate the effects of an African-specific CYP2D6 variant allele, CYP2D6*17, on the pharmacokinet...

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Detalles Bibliográficos
Autores principales: Kanji, Comfort Ropafadzo, Nyabadza, Georginah, Nhachi, Charles, Masimirembwa, Collen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961245/
https://www.ncbi.nlm.nih.gov/pubmed/36836506
http://dx.doi.org/10.3390/jpm13020272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961245/
https://www.ncbi.nlm.nih.gov/pubmed/36836506
http://dx.doi.org/10.3390/jpm13020272

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