Rescue of Rare CFTR Trafficking Mutants Highlights a Structural Location-Dependent Pattern for Correction

Cystic Fibrosis (CF) is a genetic disease caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel. Currently, more than 2100 variants have been identified in the gene, with a large number being very rare. The approval of modulators that act on...

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Detalles Bibliográficos
Autores principales: Zacarias, Sónia, Batista, Marta S. P., Ramalho, Sofia S., Victor, Bruno L., Farinha, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961391/
https://www.ncbi.nlm.nih.gov/pubmed/36834620
http://dx.doi.org/10.3390/ijms24043211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961391/
https://www.ncbi.nlm.nih.gov/pubmed/36834620
http://dx.doi.org/10.3390/ijms24043211

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