The Combination of an mRNA Immunogen, a TLR7 Agonist and a PD1 Blocking Agent Enhances In-Vitro HIV T-Cell Immune Responses

The development of new strategies to achieve a functional cure for HIV remains a priority. We tested a novel HIV therapeutic vaccine using unmodified mRNA (TMEP-B) and mRNA modified by 1-methyl-3′-pseudouridylyl (TMEP-Bmod) expressing both a multiepitopic sequences from Gag, Pol, and Nef proteins, i...

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Detalles Bibliográficos
Autores principales: Usero, Lorena, Leal, Lorna, Gómez, Carmen Elena, Miralles, Laia, Aurrecoechea, Elena, Esteban, Ignasi, Torres, Berta, Inciarte, Alexy, Perdiguero, Beatriz, Esteban, Mariano, García, Felipe, Plana, Montserrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961394/
https://www.ncbi.nlm.nih.gov/pubmed/36851164
http://dx.doi.org/10.3390/vaccines11020286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961394/
https://www.ncbi.nlm.nih.gov/pubmed/36851164
http://dx.doi.org/10.3390/vaccines11020286

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