Orally Delivered Connexin43 Hemichannel Blocker, Tonabersat, Inhibits Vascular Breakdown and Inflammasome Activation in a Mouse Model of Diabetic Retinopathy

Diabetic retinopathy (DR), a microvascular complication of diabetes, is associated with pronounced inflammation arising from the activation of a nucleotide-binding and oligomerization domain-like receptor (NLR) protein 3 (NLRP3) inflammasome. Cell culture models have shown that a connexin43 hemichan...

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Detalles Bibliográficos
Autores principales: Mugisho, Odunayo O., Aryal, Jyoti, Shome, Avik, Lyon, Heather, Acosta, Monica L., Green, Colin R., Rupenthal, Ilva D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961562/
https://www.ncbi.nlm.nih.gov/pubmed/36835288
http://dx.doi.org/10.3390/ijms24043876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961562/
https://www.ncbi.nlm.nih.gov/pubmed/36835288
http://dx.doi.org/10.3390/ijms24043876

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