Cargando…

TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection

The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into lung cells, and TMPRSS2 inhibitors are being developed for COVID-19 therapy. However, the SARS-CoV-2 Omicron variant, which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Metzdorf, Kristin, Jacobsen, Henning, Greweling-Pils, Marina C., Hoffmann, Markus, Lüddecke, Tatjana, Miller, Felicitas, Melcher, Lars, Kempf, Amy M., Nehlmeier, Inga, Bruder, Dunja, Widera, Marek, Ciesek, Sandra, Pöhlmann, Stefan, Čičin-Šain, Luka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961888/ https://www.ncbi.nlm.nih.gov/pubmed/36851486 http://dx.doi.org/10.3390/v15020271

Ejemplares similares

Long-term immune protection against SARS-CoV-2 escape variants upon a single vaccination with murine cytomegalovirus expressing the spike protein
por: Kim, Yeonsu, et al.
Publicado: (2022)

Systematical assessment of the impact of single spike mutations of SARS-CoV-2 Omicron sub-variants on the neutralization capacity of post-vaccination sera
por: Katzmarzyk, Maeva, et al.
Publicado: (2023)

Post-vaccination T cell immunity to omicron
por: Jacobsen, Henning, et al.
Publicado: (2022)

Native and activated antithrombin inhibits TMPRSS2 activity and SARS‐CoV‐2 infection
por: Wettstein, Lukas, et al.
Publicado: (2022)

Omicron sublineage BQ.1.1 resistance to monoclonal antibodies
por: Arora, Prerna, et al.
Publicado: (2023)

Diminished neutralization responses towards SARS-CoV-2 Omicron VoC after mRNA or vector-based COVID-19 vaccinations
por: Jacobsen, Henning, et al.
Publicado: (2022)

H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice
por: Lambertz, Ruth Lydia Olga, et al.
Publicado: (2020)

Effect of hybrid immunity and bivalent booster vaccination on omicron sublineage neutralisation
por: Hoffmann, Markus, et al.
Publicado: (2023)

Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity
por: Rand, Ulfert, et al.
Publicado: (2021)

Augmented neutralisation resistance of emerging omicron subvariants BA.2.12.1, BA.4, and BA.5
por: Arora, Prerna, et al.
Publicado: (2022)

Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2
por: Reinke, Lennart Michel, et al.
Publicado: (2017)

Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge
por: Zheng, Xiaoyan, et al.
Publicado: (2019)

Evaluation of the Neutralizing Antibody STE90-C11 against SARS-CoV-2 Delta Infection and Its Recognition of Other Variants of Concerns
por: Abassi, Leila, et al.
Publicado: (2023)

The SARS-CoV-2 Delta-Omicron Recombinant Lineage (XD) Exhibits Immune-Escape Properties Similar to the Omicron (BA.1) Variant
por: Arora, Prerna, et al.
Publicado: (2022)

Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin
por: Zmora, Pawel, et al.
Publicado: (2017)

SARS-CoV-2 delta variant neutralisation after heterologous ChAdOx1-S/BNT162b2 vaccination
por: Behrens, Georg MN, et al.
Publicado: (2021)

Lung cell entry, cell–cell fusion capacity, and neutralisation sensitivity of omicron sublineage BA.2.75
por: Arora, Prerna, et al.
Publicado: (2022)

Omicron subvariant BA.5 efficiently infects lung cells
por: Hoffmann, Markus, et al.
Publicado: (2023)

The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic
por: Hoffmann, Markus, et al.
Publicado: (2022)

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates
por: Bojkova, Denisa, et al.
Publicado: (2022)

No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2
por: Arora, Prerna, et al.
Publicado: (2022)

Polyvalent Nano-Lectin Potently Neutralizes SARS-CoV-2 by Targeting Glycans on the Viral Spike Protein
por: Budhadev, Darshita, et al.
Publicado: (2023)

Route, origin & valence matter: towards sophisticated next-generation vaccines to cope with the COVID-19 pandemic
por: Volckmar, Julia, et al.
Publicado: (2022)

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
por: Meng, Bo, et al.
Publicado: (2022)

Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
por: Shalamova, Lyudmila, et al.
Publicado: (2022)

Vaccine Vectors Harnessing the Power of Cytomegaloviruses
por: Ynga-Durand, Mario Alberto, et al.
Publicado: (2019)

A Novel Triple-Fluorescent HCMV Strain Reveals Gene Expression Dynamics and Anti-Herpesviral Drug Mechanisms
por: Rand, Ulfert, et al.
Publicado: (2021)

Foscarnet-Type Inorganic-Organic Hybrid Nanoparticles for Effective Antiviral Therapy
por: Khorenko, Mikhail, et al.
Publicado: (2022)

Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture
por: Wettstein, Lukas, et al.
Publicado: (2022)

SARS-CoV-2 Omicron Specific Mutations Affecting Infectivity, Fusogenicity, and Partial TMPRSS2-Independency
por: Strobelt, Romano, et al.
Publicado: (2023)

TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells
por: Zmora, Pawel, et al.
Publicado: (2015)

Efficient antibody evasion but reduced ACE2 binding by the emerging SARS-CoV-2 variant B.1.640.2
por: Arora, Prerna, et al.
Publicado: (2022)

Early Detection of SARS-CoV-2 Omicron BA.4 and BA.5 in German Wastewater
por: Wilhelm, Alexander, et al.
Publicado: (2022)

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination
por: Kim, Yeonsu, et al.
Publicado: (2022)

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases
por: Chaudhry, M. Zeeshan, et al.
Publicado: (2022)

Wastewater surveillance allows early detection of SARS-CoV-2 omicron in North Rhine-Westphalia, Germany
por: Wilhelm, Alexander, et al.
Publicado: (2022)

Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins
por: Wrensch, Florian, et al.
Publicado: (2017)

Integrated coastal and ocean management : concepts and practices
por: Cicin-Sain, Biliana
Publicado: (1998)

The effect of cilgavimab and neutralisation by vaccine-induced antibodies in emerging SARS-CoV-2 BA.4 and BA.5 sublineages
por: Arora, Prerna, et al.
Publicado: (2022)

Delta variant (B.1.617.2) sublineages do not show increased neutralization resistance
por: Arora, Prerna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vckmu7shhdame6cv4ops58br7p