In Silico Investigation of the Molecular Mechanism of PARP1 Inhibition for the Treatment of BRCA-Deficient Cancers

The protein PARP1, which plays a crucial role in DNA repair processes, is an attractive target for cancer therapy, especially for BRCA-deficient cancers. To overcome the acquired drug resistance of PARP1, PARP1 G-quadruplex (G4) identified in the PARP1-promotor region is gaining increasing attention...

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Detalles Bibliográficos
Autores principales: Yan, Fengqin, Fu, Zhenfu, Li, Guo, Wang, Zhiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961911/
https://www.ncbi.nlm.nih.gov/pubmed/36838818
http://dx.doi.org/10.3390/molecules28041829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961911/
https://www.ncbi.nlm.nih.gov/pubmed/36838818
http://dx.doi.org/10.3390/molecules28041829

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