A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective Autophagy via the PDK1/Akt Signaling Pathway in Non-Small Cell Lung Cancer

In a preliminary study, we synthesized a series of new PDK1/MEK dual inhibitors. Antitumor activity screening showed that Compound YZT exerts a strong inhibitory action in A549 cells. However, the specific mechanism of YZT against non-small cell lung cancer (NSCLC) is largely unknown. This work conf...

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Detalles Bibliográficos
Autores principales: Liu, Rangru, Chen, Zhuo, Hu, Gaoyun, Yu, Zutao, Li, Qianbin, Liu, Danqi, Li, Ling, Liu, Zhaoqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961937/
https://www.ncbi.nlm.nih.gov/pubmed/37259393
http://dx.doi.org/10.3390/ph16020244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961937/
https://www.ncbi.nlm.nih.gov/pubmed/37259393
http://dx.doi.org/10.3390/ph16020244

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