Cargando…

Metformin Directly Binds to MMP-9 to Improve Plaque Stability

Vulnerable atherosclerotic plaque rupture is the principal mechanism that accounts for myocardial infarction and stroke. High matrix metalloproteinase-9 (MMP-9) expression and activity have been proven to lead to plaque instability. Metformin, a first-line treatment for type 2 diabetes, is beneficia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Xianda, Wang, Shuaixing, Xu, Wenli, Zhao, Mingming, Zhang, Youyi, Xiao, Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962015/ https://www.ncbi.nlm.nih.gov/pubmed/36826550 http://dx.doi.org/10.3390/jcdd10020054

Ejemplares similares

Assessment of Carotid Plaque Stability Using Contrast-Enhanced Ultrasound and Its Correlation With the Expression of CD147 and MMP-9 in the Plaque
por: Huang, Shanshan, et al.
Publicado: (2021)

Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP-2 and MMP-9 were associated with acute cerebral infarction
por: Chen, Lilin, et al.
Publicado: (2018)

Correlations of MMP-1, MMP-3, and MMP-12 with the degree of atherosclerosis, plaque stability and cardiovascular and cerebrovascular events
por: Hu, Wei, et al.
Publicado: (2018)

Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP‐9 expression but not direct TJ proteins expression regulation
por: Zhang, Di, et al.
Publicado: (2017)

Structural insights into the binding of MMP9 inhibitors
por: Tandon, Arpit, et al.
Publicado: (2011)

Videodensitometric analysis of advanced carotid plaque: correlation with MMP-9 and TIMP-1 expression
por: Baroncini, Liz Andréa V, et al.
Publicado: (2011)

Myeloperoxidase-oxidized high density lipoprotein impairs atherosclerotic plaque stability by inhibiting smooth muscle cell migration
por: Zhou, Boda, et al.
Publicado: (2017)

MMP‐1 and MMP‐9 regulate epidermal growth factor‐dependent collagen loss in human carotid plaque smooth muscle cells
por: Rao, Velidi H., et al.
Publicado: (2014)

Liposomal Tumor Targeting in Drug Delivery Utilizing MMP-2- and MMP-9-Binding Ligands
por: Penate Medina, Oula, et al.
Publicado: (2011)

Binding of amelogenin to MMP-9 and their co-expression in developing mouse teeth
por: Feng, Junsheng, et al.
Publicado: (2012)

Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells
por: ESFAHANIAN, NILUFAR, et al.
Publicado: (2012)

Selective binding of matrix metalloproteases MMP-9 and MMP-12 to inhibitor-assisted thermolysin-imprinted beads
por: Schauer, Nicole, et al.
Publicado: (2018)

Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours
por: Tan, Mei Lin, et al.
Publicado: (2010)

Exercise Training Attenuates Acute β-Adrenergic Receptor Activation-Induced Cardiac Inflammation via the Activation of AMP-Activated Protein Kinase
por: Zhang, Mi, et al.
Publicado: (2023)

Assessment of MMP-9, TIMP-1, and COX-2 in normal tissue and in advanced symptomatic and asymptomatic carotid plaques
por: V Baroncini, Liz Andréa, et al.
Publicado: (2011)

Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis
por: Beldman, Thijs J., et al.
Publicado: (2017)

Direct association between diet and the stability of human atherosclerotic plaque
por: Gonçalves, Isabel, et al.
Publicado: (2015)

LOX inhibition downregulates MMP-2 and MMP-9 in gastric cancer tissues and cells
por: Zhao, Lei, et al.
Publicado: (2019)

MMP-9 overexpression is associated with intragenic hypermethylation of MMP9 gene in melanoma
por: Falzone, Luca, et al.
Publicado: (2016)

The Role of MMP-9 and MMP-9 Inhibition in Different Types of Thyroid Carcinoma
por: Li, Zhenshengnan, et al.
Publicado: (2023)

MMP2 and MMP9 associate with crescentic glomerulonephritis
por: Phillips, Tessa M., et al.
Publicado: (2017)

The role of MMP-2 and MMP-9 in the metastasis and development of hypopharyngeal carcinoma
por: Song, Zhe, et al.
Publicado: (2019)

A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability
por: Xia, Bing, et al.
Publicado: (2019)

Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances
por: Huang, Hao
Publicado: (2018)

Sonodynamic therapy suppresses matrix collagen degradation in vulnerable atherosclerotic plaque by modulating caspase 3 - PEDF/HIF-1α - MMP-2/MMP-9 signaling in macrophages
por: Tian, Yanfeng, et al.
Publicado: (2022)

Immunoexpression of MMP-8 and MMP-9 in chronic subdural hematoma
por: Su, Gao-Jian, et al.
Publicado: (2022)

Correlation of MMP-3 and MMP-9 with Crohn’s Disease Activity in Children
por: Kofla-Dlubacz, Anna, et al.
Publicado: (2011)

Inhibition of MMP-2 and MMP-9 Activities by Limonium tetragonum Extract
por: Bae, Min-Joo, et al.
Publicado: (2016)

Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma
por: Goździalska, Anna, et al.
Publicado: (2016)

The involvement of MMP-2 and MMP-9 in heart exercise-related angiogenesis
por: Bellafiore, Marianna, et al.
Publicado: (2013)

Bruxism Throughout the Lifespan and Variants in MMP2, MMP9 and COMT
por: Vieira, Alexandre R., et al.
Publicado: (2020)

Quantification of matrix metalloproteinases MMP-8 and MMP-9 in gingival overgrowth
por: Orozco-Páez, Jennifer, et al.
Publicado: (2021)

Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas
por: Meneses-García, Abelardo, et al.
Publicado: (2008)

MMP-9 Levels and NaOCl Lavage in Randomized Trial on Direct Pulp Capping
por: Ballal, N.V., et al.
Publicado: (2021)

Activation of MMP‐9 by membrane type‐1 MMP/MMP‐2 axis stimulates tumor metastasis
por: Li, Zichen, et al.
Publicado: (2017)

Metformin Alleviates Endometriosis and Potentiates Endometrial Receptivity via Decreasing VEGF and MMP9 and Increasing Leukemia Inhibitor Factor and HOXA10
por: Cheng, Jing, et al.
Publicado: (2022)

Matrix Metalloproteinases MMP2 and MMP9 Are Produced in Early Stages of Kidney Morphogenesis but Only MMP9 Is Required for Renal Organogenesis In Vitro
por: Lelongt, Brigitte, et al.
Publicado: (1997)

The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer
por: Kudelski, Jacek, et al.
Publicado: (2023)

Assessing the value of matrix metalloproteinase 9 (MMP9) in improving the appropriateness of referrals for colorectal cancer
por: Damery, S, et al.
Publicado: (2013)

Logistic Regression Analysis of Clinical Characteristics for Differentiation of Chronic Obstructive Pulmonary Disease Severity
por: Guo, Shuaixing
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_30ch7pkktik21vivadgqknt5eu