The Mechanism of Metal-Containing Formate Dehydrogenases Revisited: The Formation of Bicarbonate as Product Intermediate Provides Evidence for an Oxygen Atom Transfer Mechanism

Mo/W-containing formate dehydrogenases (FDH) catalyzed the reversible oxidation of formate to carbon dioxide at their molybdenum or tungsten active sites. While in the reaction of formate oxidation, the product is CO(2), which exits the active site via a hydrophobic channel; bicarbonate is formed as...

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Detalles Bibliográficos
Autores principales: Kumar, Hemant, Khosraneh, Maryam, Bandaru, Siva S. M., Schulzke, Carola, Leimkühler, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962302/
https://www.ncbi.nlm.nih.gov/pubmed/36838526
http://dx.doi.org/10.3390/molecules28041537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962302/
https://www.ncbi.nlm.nih.gov/pubmed/36838526
http://dx.doi.org/10.3390/molecules28041537

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