Photocaging of Pyridinylimidazole-Based Covalent JNK3 Inhibitors Affords Spatiotemporal Control of the Binding Affinity in Live Cells

The concept of photocaging represents a promising approach to acquire spatiotemporal control over molecular bioactivity. To apply this strategy to pyridinylimidazole-based covalent JNK3 inhibitors, we used acrylamido-N-(4-((4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)...

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Detalles Bibliográficos
Autores principales: Hoffelner, Beate Sandra, Andreev, Stanislav, Plank, Nicole, Koch, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962329/
https://www.ncbi.nlm.nih.gov/pubmed/37259409
http://dx.doi.org/10.3390/ph16020264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962329/
https://www.ncbi.nlm.nih.gov/pubmed/37259409
http://dx.doi.org/10.3390/ph16020264

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