A Computational Inter-Species Study on Safrole Phase I Metabolism-Dependent Bioactivation: A Mechanistic Insight into the Study of Possible Differences among Species

Safrole, a 162.2 Da natural compound belonging to the alkenylbenzenes class, is classified as a possible carcinogen to humans by IARC (group IIB) and has proven to be genotoxic and carcinogenic to rodents. Despite its use as a food or feed additive, it is forbidden in many countries due to its docum...

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Detalles Bibliográficos
Autores principales: Pedroni, Lorenzo, Louisse, Jochem, Punt, Ans, Dorne, Jean Lou C. M., Dall’Asta, Chiara, Dellafiora, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962551/
https://www.ncbi.nlm.nih.gov/pubmed/36828409
http://dx.doi.org/10.3390/toxins15020094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962551/
https://www.ncbi.nlm.nih.gov/pubmed/36828409
http://dx.doi.org/10.3390/toxins15020094

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