Synthesis of 4′-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents

Over the past decades, both 4′-modified nucleoside and carbocyclic nucleoside analogs have been under the spotlight as several compounds from either family showed anti-HIV, HCV, RSV or SARS-CoV-2 activity. Herein, we designed compounds combining these two features and report the synthesis of a serie...

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Detalles Bibliográficos
Autores principales: Biteau, Nicolas G., Amichai, Sarah A., Azadi, Niloufar, De, Ramyani, Downs-Bowen, Jessica, Lecher, Julia C., MacBrayer, Tamara, Schinazi, Raymond F., Amblard, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962574/
https://www.ncbi.nlm.nih.gov/pubmed/36851758
http://dx.doi.org/10.3390/v15020544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962574/
https://www.ncbi.nlm.nih.gov/pubmed/36851758
http://dx.doi.org/10.3390/v15020544

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