Integrating Siderophore Substructures in Thiol-Based Metallo-β-Lactamase Inhibitors

Metallo beta lactamases (MBLs) are among the most problematic resistance mechanisms of multidrug-resistant Gram-negative pathogens due to their broad substrate spectrum and lack of approved inhibitors. In this study, we propose the integration of catechol substructures into the design of thiol-based...

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Detalles Bibliográficos
Autores principales: Rotter, Marco J., Zentgraf, Sabrina, Weizel, Lilia, Frank, Denia, Burgers, Luisa D., Brunst, Steffen, Fürst, Robert, Proschak, Anna, Wichelhaus, Thomas A., Proschak, Ewgenij
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962638/
https://www.ncbi.nlm.nih.gov/pubmed/36838971
http://dx.doi.org/10.3390/molecules28041984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962638/
https://www.ncbi.nlm.nih.gov/pubmed/36838971
http://dx.doi.org/10.3390/molecules28041984

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