High-Dose Primaquine Induces Proximal Tubular Degeneration and Ventricular Cardiomyopathy Linked to Host Cells Mitochondrial Dysregulation

Primaquine (PQ) is the only antimalarial medication used to eradicate many species of Plasmodium gametocytes and prevent relapse in vivax and ovale malarias. PQ metabolites induce oxidative stress and impair parasitic mitochondria, leading to protozoal growth retardation and death. Collateral damage...

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Detalles Bibliográficos
Autores principales: Rabiablok, Atthasit, Hanboonkunupakarn, Borimas, Tuentam, Khwanchanok, Fongsodsri, Kamonpan, Kanjanapruthipong, Tapanee, Ampawong, Sumate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962680/
https://www.ncbi.nlm.nih.gov/pubmed/36851021
http://dx.doi.org/10.3390/toxics11020146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962680/
https://www.ncbi.nlm.nih.gov/pubmed/36851021
http://dx.doi.org/10.3390/toxics11020146

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