In Silico and In Vitro Screening of Serine Racemase Agonist and In Vivo Efficacy on Alzheimer’s Disease Drosophila melanogaster

The NMDA receptor hypofunction has been implicated in schizophrenia, memory impairment, and Alzheimer’s disease. Modulating the abundance of D-serine, a co-agonist of the NMDA receptor, is a strategy to treat symptoms of the NMDA receptor hypofunction. In contrast to D-amino acid oxidase (DAAO) inhi...

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Detalles Bibliográficos
Autores principales: Lu, Chih-Hao, Chang, Hao-Teng, Hsu, Lee-Fen, Lee, Ming-Hsueh, Cheng, Jack, Wu, Dong Chuan, Lin, Wei-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962741/
https://www.ncbi.nlm.nih.gov/pubmed/37259423
http://dx.doi.org/10.3390/ph16020280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962741/
https://www.ncbi.nlm.nih.gov/pubmed/37259423
http://dx.doi.org/10.3390/ph16020280

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