PKD autoinhibition in trans regulates activation loop autophosphorylation in cis

Phosphorylation is a ubiquitous mechanism by which signals are transduced in cells. Protein kinases, enzymes that catalyze the phosphotransfer reaction are, themselves, often regulated by phosphorylation. Paradoxically, however, a substantial fraction of more than 500 human protein kinases are capab...

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Detalles Bibliográficos
Autores principales: Reinhardt, Ronja, Hirzel, Kai, Link, Gisela, Eisler, Stephan A., Hägele, Tanja, Parson, Matthew A. H., Burke, John E., Hausser, Angelika, Leonard, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962925/
https://www.ncbi.nlm.nih.gov/pubmed/36745811
http://dx.doi.org/10.1073/pnas.2212909120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962925/
https://www.ncbi.nlm.nih.gov/pubmed/36745811
http://dx.doi.org/10.1073/pnas.2212909120

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