Common activities and predictive gene signature identified for genetic hypomorphs of TP53

Missense mutations that inactivate p53 occur commonly in cancer, and germline mutations in TP53 cause Li Fraumeni syndrome, which is associated with early-onset cancer. In addition, there are over two hundred germline missense variants of p53 that remain uncharacterized. In some cases, these germlin...

Descripción completa

Detalles Bibliográficos
Autores principales: Leung, Jessica C., Leu, Julia I-Ju, Indeglia, Alexandra, Kannan, Toshitha, Clarke, Nicole L., Kirven, Nicole A., Dweep, Harsh, Garlick, David, Barnoud, Thibaut, Kossenkov, Andrew V., George, Donna L., Murphy, Maureen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962931/
https://www.ncbi.nlm.nih.gov/pubmed/36749725
http://dx.doi.org/10.1073/pnas.2212940120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9962931/
https://www.ncbi.nlm.nih.gov/pubmed/36749725
http://dx.doi.org/10.1073/pnas.2212940120

Ejemplares similares