TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs

Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by the lack of dystrophin. Heart failure, driven by cardiomyocyte death, fibrosis, and the development of dilated cardiomyopathy, is the leading cause of death in DMD patients. Current treatments decrease the mechanical load...

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Detalles Bibliográficos
Autores principales: Eguchi, Asuka, Gonzalez, Adriana Fernanda G. S., Torres-Bigio, Sofía I., Koleckar, Kassie, Birnbaum, Foster, Zhang, Joe Z., Wang, Vicky Y., Wu, Joseph C., Artandi, Steven E., Blau, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963063/
https://www.ncbi.nlm.nih.gov/pubmed/36719921
http://dx.doi.org/10.1073/pnas.2209967120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963063/
https://www.ncbi.nlm.nih.gov/pubmed/36719921
http://dx.doi.org/10.1073/pnas.2209967120

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